With me today is Dr Thomas Seyfried he’s a professor at Boston College and a prominent researcher in the field of cancer biology and metabolic Theory like the super is really a pleasure to chat to you well thank you very much Nadia it’s nice to hear be here and speak with you as well I can hardly believe my luck I mean this room never really happens but an international team of researchers had a study that was reported on today and you were going to be co-authors which found a non-toxic combination pairing a specialized diet and a tumor fighting drug which destroys two major cells in an aggressive diablastoma it’s an aggressive brain cancer this is groundbreaking can you talk me through this study the findings yes um well we know uh brain cancer especially glioblastoma uh is is like one of the worst if not the worst type of of cancer that a person a person can have and also little kids children can have pineal blastomas they’re very similar uh except they they occur in a younger brain but their outcome is just as as devastating um what what we have uh identified over many many years of research um based on Otto warburg’s original observations all of the different neoplastic cells inside of a glioblastoma are predominantly using a fermentation metabolismImagine your body as a bustling factory. In this factory, “metabolize” is the process of taking raw materials (like food) and transforming them into usable products (like energy). It’s the complex network of chemical reactions that sustains living things, ensuring… Read More to generate energy and what that essentially means is they generate energy without the use of oxygen and um and what they call a glial they used to call it glioblastoma multi-formy because this types of cells that were in there were always so complicated and dysmorphic and all this kind of stuff and you know many many Studies have shown hundreds and thousands of gene mutations and all these kinds of cells but according to our metabolic hypothesis the mitochondrialImagine tiny power plants inside your cells, constantly working to keep you energized. That’s exactly what mitochondria are! These sausage-shaped organelles are the champions of cellular respiration, the process that generates most of the energy your body needs to function…. Read More metabolic theory of cancer um the originWhat is an origin? An origin is the starting point, the place or source where something begins. It’s like the very first chapter in the story of that thing. Examples: • The origin of a river: Where the river first… Read More of the of the disease arises from damage to the respiration of the cells and all of the cells then would have to ferment that is generate energy without oxygen regardless of what the cells look like all the neoplastic cells in in the glioblastoma are using energy without oxygen and that comes from just two fuels glucose and glutamine the sugarIn everyday terms, sugar refers to the sweet, crystalline substance we add to coffee, bake into cakes, or find naturally in fruits. But from a scientific perspective, sugar encompasses a broader category of molecules called carbohydrates. These are the body’s… Read More glucose and the amino acidAmino acids are the tiny building blocks that make up proteins, which are essential for almost every process in your body. Think of them like Legos – different combinations of these small pieces can create all sorts of structures, from… Read More glutamine one of the problems with glioblastoma it’s a horrible horrible survival statistics which have not changed in almost 100 years if you can believe this when you when you think about all of the accomplishments of humankind in the last hundred years uh astonishing advances in science and technology a web telescope that orbits the earth a million miles and could look at the origin and yet we have not made one major advance in keeping people alive with glioblastoma can you believe this and one of the there’s a couple of major problems with this is one is the misunderstanding of what cancer is and including glioblastoma it’s not a genetic disease it’s a metabolic disease that’s number number one number two is that continue to radiationRadiation is invisible energy that moves around like super-fast waves or tiny packets of energy. It’s kind of like when you feel the heat from a campfire, even if you’re not touching the fire. Where did the word come from?… Read More of the brain in people that have these tumors and we have published very very clear evidence that when you take when a person is diagnosed with glioblastoma the radiation of the brain frees up the two fuels the metabolic fuels the glucose and the glutamine needed uh to drive the growth of the tumor so the very process of treating a person a person with it’s bad enough that the person has this tumor it’s worse when you treat it with a therapy that frees up the two fuels that drive the tumor leading to the rapid death and demise of the majority of people that have these tumors there will be no advance in managing glioblastoma until we stop irradiating the brain of people that have glioblastoma I have published and my colleagues have published papers upon papers showing the details of what I’m saying yet it’s whatever reason it is ignored by the scientific Community I have no idea what what could account for someone to use a therapy that would lead to the rapid demise of their very patients yet we have shown when you irradiate the brain you free up the two fuels that drive energy without oxygen that is the sugar glucose and the amino acidA Deep Dive into pH, Health, and Everyday Life Have you ever puckered your lips after biting into a lemon or felt a burning sensation in your chest after a spicy meal? That’s the tangy sensation of acidity in action…. Read More glutamine the glucose listen when you irradiate somebody blood sugarBlood sugar, also known as blood glucose, is a type of simple sugar circulating in your bloodstream. It can be a primary source of energy for your cells. Your body can get blood sugar from carbohydrates that you eat. The… Read More goes up high and the bread the brain the head begins to warm because of the radiation so you give high-dose steroids which make bloodBlood is the life force coursing through your veins and arteries, delivering vital oxygen and nutrients to every cell in your body while whisking away waste products. It’s a complex, dynamic fluid—not just a simple red liquid. Consider it a… Read More sugar go even higher the radiation breaks apart these very intricate psych cell uh connections between neurons and glia freeing up massive amounts of glutamine it’s unbelievable and then these poor folks are all dying the the the death from glioblastoma is so reproducible in every major medical school throughout the world it’s unbelievable you cannot design a more perfect experiment to lead to the demise of your patients than the current standard of careKey Sections to Include:Understanding Standards of Care: Your Guide to Safe and Effective Healthcare Imagine embarking on a road trip without a map or GPS. You’d likely get lost, make wrong turns, and potentially encounter dangerous situations. In the realm… Read More for glioblastoma I have no clue how the words that I am saying are completely misunderstood by anyone treating patients with glioblastoma it’s unbelievable so we have a a person that chose no radiation no chemo no no none of this and he’s still alive in England Pablo KellyCancer Survivor Pablo Kelly: Testimonial w/ Dr. Seyfried’s metabolic approach (Grade 4 Glioblastoma) Read More um he said I don’t want radiation I don’t want chemo I don’t want any of this stuff he had surgery we think surgery is an extremely important tool for managing glioblastoma um if you if you can get rid of the tumor both debulking we call it debulking and metabolic therapy can shrink the tumor so surgical debulking becomes even more effective so we think surgery is absolutely essential for the management of glioblastoma if done correctly with metabolic therapy a therapy that restricts the availability of the glucose and the glutamine does not disturb the tumor micro environment so we can shrink it down reduce the inflammationInflammation is your body’s natural response to injury or infection. Imagine it like a fire alarm going off in your body, sending out signals to fight off invaders and heal damaged tissues. • Other Names: You might not hear many other… Read More surgery can take the majority of this tumor out and we think patients will live far far longer than they do today if they do things the correct way first of all you have to realize it’s not a genetic disease so get over this crazy stuff about trying to Target mutations and all this stuff that’s based on a a a a a a wrong Theory it’s a metabolic Theory it can’t live without glucose and glutamine and they also can’t use fatty acids or Ketone bodiesKetones, organic compounds produced by the liver, are the unsung heroes of energy metabolism, stepping in when glucose, the body’s primary fuel, becomes scarce. Think of them as a reserve power generator, kicking into gear when the main power supply… Read More so they so a man a successful management for glioblastoma becomes transitioning the patient over the nutritional ketosisUnlocking the Secrets of Nutritional Ketosis: A Comprehensive Guide Imagine your body as a hybrid car, capable of running on two distinct fuel sources: gasoline (carbohydrates) and electricity (fat). Nutritional ketosis is like switching your body’s engine from gasoline to… Read More lowers blood sugar elevates Ketone bodies which the tumor cells cannot use so you marginalize them and then you come in with drugs and procedures to Target glucose and glutamine this will allow patients to stay alive two three four times longer than they and with a higher quality of life why is this not done we have to start asking the medical community why is this not done and that’s the the great mystery and if people want to challenge this all you have to do is look at the survival statistics and understand the metabolism of cancer and you will understand why your patients aren’t surviving it seems to me from what you’re saying that tense is an environmental and a lifestyle disease well I mean there’s no way we don’t know what the cause is of glioblastone it could have many many different causes so a life it’s not a lifestyle issue with respect to its origin it can be a lifestyle modification once the tumor is diagnosed so the origin of glioblastoma can come from viral infectionsAn infection is like a party crasher in your body. It happens when harmful germs, like bacteria or viruses, invade your body tissues and start reproducing. This unwelcome invasion can disrupt your body’s normal functions, including your metabolism. • Synonyms: Well-documented… Read More that come from trauma to the Head it can come from exposure to chemicals it can come from a lot of different reasons but once you have that diagnosis then there becomes a clear strategy for managing that cancer uh very very different than what we’re doing to these patients today well you mentioned that it can be treated with metabolic therapiesImagine your body is a complex machine, with metabolism as its engine, transforming food into energy. Metabolic therapy is a revolutionary approach to health and disease management that fine-tunes this engine, optimizing its function for optimal well-being. It’s like a… Read More um ketogenic diet1. Simple Definition: Imagine your body is like a hybrid car with two fuel tanks: one for gasoline (sugar) and one for electricity (ketones). The ketogenic diet, or keto diet, is like switching your car’s engine to run primarily on… Read More as far as I understand is one of those what are the metabolic therapiesTherapy is a broad term encompassing various treatment approaches aimed at improving health and well-being. It’s like a toolkit with various tools designed to address specific ailments and promote healing. While often associated with mental health, therapy extends far beyond… Read More and what do they entail well okay well the the ketogenic diet uh or calorie restriction or say water only fastingFasting simply means abstaining from food, and sometimes drinks, for a set period. It’s a practice observed across cultures and throughout history, for various reasons. What is fasting? Think of fasting as giving your body a break from eating. Instead… Read More any any of these procedures what they do is they lower the blood sugar that’s needed to drive the tumor they’re also powerfully anti-inflammatory so many of these cancers are loaded with tremendous amounts of inflammation the micro environment is is inflamed all of that stuff can be significantly reduced if uh water people say well water only fasting who can do that well you have a choice you can either do that or you can die from the tumor I mean there’s there’s not you don’t have many options um but on the other hand a calorie restricted ketogenic diet or any diet that lowers blood sugar and elevates ketones which we have shown we’ve actually developed the glucose Ketone indexThe Glucose Ketone Index (GKI) is a simple yet powerful tool for understanding your body’s energy balance. It acts like a gauge, revealing how efficiently your body is burning fuel. Imagine your body as a hybrid car that can run… Read More monitor to allow cancer patients not only glioblastoma almost all cancers are very similar similar they’re all fermenters they all they all need glucose and glutamine um you know you have a a meter that can be used the keto Mojo meter that can be used to tell a cancer patients how low their blood sugar is and how either ketones are and when they get into a particular Zone you’re going to be killing tumor cells uh once that once you get into that zone then we then we use glutamine targeting drugs as a matter of fact um that one of the big challenges in managing brain cancer is delivering drugs through what we call the blood-brain barrier when you when you put a patient into therapeutic nutritional ketosisA Deep Dive into the Metabolic State Transforming Health and Wellness Imagine your body as a hybrid car, capable of running on two distinct fuel sources: gasoline (carbohydrates) and electricity (fat). Ketosis is like switching your body’s engine from gasoline… Read More you can easily deliver small moleculesImagine tiny building blocks that come together to form everything around you, from water to air to your own body! A molecule is a group of two or more atoms held together by strong forces called chemical bonds. Think of… Read More to the to the tumor we publish papers showing this you don’t need some fancy chemical you just have to put the patient into therapeutic ketosisUnleashing the Power of Therapeutic Ketosis: A Deep Dive Imagine your body as a car with a dual-fuel engine. It can run on either gasoline (glucose from carbohydrates) or electricity (ketones from fat). Therapeutic ketosis is like intentionally switching your… Read More and then deliver glutamine targeting drugs small quantities of these you don’t even need a lot very small amounts of these drugs will be massively effective when when used with uh ketogenic metabolic therapy so it’s a diet drug Synergy to manage these cancers without causing toxicity“Toxic” means something that’s poisonous or really harmful. It’s like something bad that can make you sick or even hurt you. Where did the word come from? A long, long time ago, people who used bows and arrows would put… Read More is a nice thing too you don’t have to have your hair fall out you have to have all these horrible nausea and vomiting and all this kind of crazy stuff you can actually manage the candy I mean yes you’ll feel hungry on occasion but your body gets to adjust this it adapts you adapt to this and the tumor cells get hammered and they start shriveling up and dying and and the patients live a lot longer with a much higher quality of life and this will be the future it just takes time for people to understand what I’m saying before we go further I’d like to understand these two sort of conflicting theories of what cancer is what is the prevailing genetic theory of cancer as a disease and then the contrasting mitochondrial metabolic definition of cancer yeah well I mean right now if you go to the National Cancer Institute in the United States which is part of the NIH National institute’s Health it says right on their website cancer is a genetic disease caused by mutations I mean nothing could be further from the truth uh it’s just a it’s a a dogmatic ideology uh you know it’s a silent assumption that has been driven into the brains not only from the NCI but also throughout the world you go to England Germany they all think cancer is a genetic disease I mean we have clearly shown through nuclear transfer experiments I summarized dozens and dozens of experiments showing that uh the mutations in the nucleusImagine that a cell is like a tiny factory. The nucleus is its control center, like the boss’s office! • It contains all the instructions (DNA) the cell needs to function and grow. • The nucleus sends out messages (using… Read More cannot be the drivers of dysregulated cell growth which is cancer we have then they said well we only have to serve these driver driver mutations are the ones that are responsible for this they even turned this not all the mutations are bad only the drivers well now we’re realizing we have all of us have large numbers of driver mutations in cells that never become cancer so uh clearly uh this and also uh you know cancer is more of a modern problem than it was in the past Aboriginal tribes and uh was very rare to have to find cancer um in any of our humans that followed traditional ways ways of life our closest relatives the the chimpanzee they never documented a breast cancer breast a case of breast cancer at a female chimpanzee yet breast cancer in the United States has now replaced um heart disease is the number one killer of women uh you know so clearly the the genetics of the chimpan us are almost the same our Aboriginal ancestors are the same as us and cancer is extremely rare so it’s it’s an environmental problem uh the mutations actually come this is where we need to know what the mitochondrial metabolic theory is which arose with the work of Otto WarburgDecoding the Warburg Effect: A Journey Through the Legacy of Otto Warburg Imagine cancer cells as ravenous party guests, gorging themselves on sugar even when oxygen is readily available. This peculiar metabolic behavior, known as the Warburg effect, was first… Read More so when mitochondria become damaged they throw out which we call Ross Ros what are mitochondria oh well we have a cell all the cells in our body contain a nucleus and that has Gene the the largely our our genome most of our genome is in is in the nucleus and nucleus reproduction yeah so a cell divisionCell division is the process by which one cell splits into two new cells. This is how our bodies grow, replace old cells, and heal injuries. Normal cells go through a carefully controlled cycle of growth and division.Cancer: Division Out… Read More is needed you know the nucleus is separated and we removed it so absolutely uh you have a nucleus but you also have many other organelles you know you have various kinds of membranes lysosomes but the major the main organelle is the mitochondria this arose from an ancient bacteriaBacteria are super tiny, single-celled organisms that exist almost everywhere on Earth, including right inside you! They might seem small and insignificant, but bacteria play a big role in your health and even your metabolism. • Other Names: You might also… Read More that fused uh I don’t know maybe it was I think two 8.8 million years ago just when oxygen started to come into the atmosphere some some two and a half billion years it allowed cells to form multicellular organisms okay multicellular organ before that everyone everything we all existed at one point as a single cell living in a hypoxic environment can you believe this I mean even even even the smartest people and the greatest people in the world all started off as a single cell at one point in our existence on the planet even warbur the great Einstein existed started off as a single cell so uh at that time there was no oxygen so they just divided like crazy and it wasn’t until oxygen came into the atmosphere uh and was able to be captured by another kind of bacteria which was the origination of the mitochondria so the mitochondria is like another organism inside the cell it has its own DNADNA, short for Deoxyribonucleic Acid, is like the secret instruction manual inside every living cell. It contains all the genetic information needed to build and maintain an organism, including humans! Imagine DNA as a complex cookbook with recipes for all… Read More and it has its it is actually the controller of our existence on of the planet that the mitochondria it regulates energy metabolism inside the cell so the cell knows what to do when it when it needs to do this all driven and and the nucleus is a is kind of a slave of the mitochondria the nucleus pretty much does whatever the mitochondria thing should be done so when the mitochondria become dysfunctional and inoperable the cell reverts back to its ancient ways of disregulated cell growth and in order in order for it to grow that way it has to ferment it uses fuels that don’t require oxygen and and we and others have shown those fuels are glucose and glutamine so and the Very earliest existence of life on Earth there was fermentation fermentation is the ability to get energy ATPATP, which stands for Adenosine Triphosphate, is a molecule that acts like the energizer bunny in your cells – it keeps them going and going! It’s the primary energy currency that powers all sorts of cellular activities in your body…. Read More without oxygen and all of these cancer cells whether it’s a glioblastoma or lung cancer colon cancer breast cancer bladder cancer they’re all using a very similar common mechanism energy without oxy without oxygen fermentation so you say what can they ferment and we and others have shown it is the sugar glucose and the amino acid glutamine so if you want to kill cancer cells you must deprive them of their fermentable fuels and the strategy that requires this is based on the on the mitochondrial metabolic theory of cancer not the somatic mutation theory of cancer so once you know that cancer is driven by fermentation and the origin of cancer comes from damage to the organelle mitochondria then you know how you should be managing cancer you have to transition the whole body to a fuel that the tumor cells can’t use they cannot ferment fatty acids or Ketone bodies they can ferment only glucose and glutamine is I it’s not that complicated once you understand the global issues that you’re dealing with people just want to make everything so complicated and they’re all working under an incorrect Theory and if you’re working under an incorrect Theory you’re never going to achieve the outcome that you would have expected in the first place for me that’s just completely conflict with what you just said and that’s one of them being that the general approach to cancer is that every Cancer is different and it needs to be sort of fought on a case-to-case basis yeah that’s incorrect yeah the second just sort of big red flag is that focus on ketones and ketogenic diet and just behavioral modifications in terms of lifestyle and environment and those kinds of things have been successful in reversing type 2 diabetesDiabetes is a chronic condition where your body struggles to regulate blood sugar (glucose) levels. Glucose is like fuel for your cells, and it comes from the food you eat. Insulin, a hormone made by your pancreas, acts like a… Read More um you know doctors like Dr Chris Palmer also believes that the mental illnessism metabolic illness so it just it feels like there are just so many signs going in this direction but that leads me to what you were sort of just questioning earlier which is if it’s this obvious why so you must have some theories a health authorities are lauded for you know fighting cancer winning cancer this is how what in what makes this happening yeah you’re right about that you know I think you have to look at the institutions that are um you know dependent on cancer being a metabolic disease well correction the institutions depend that are dependent on cancer being a genetic disease yeah it’s a it’s a big industry um you know and I know to transition from what we’re currently doing which is largely ineffective uh to what could be remarkably effective it will take some time but you know um this transition then so to take time to understand what I’m saying and adapt it to the clinic unfortunately we have to sacrifice so many cancer patients um people that could be alive and doing well um we have to let them die miserably uh uh only because it takes a time it takes a while for the institutions to uh you know re-adapt themselves and say well I’m sorry you know uh we we just have to let all you folks die because we’re not really geared up to uh treat your disease the way it should be treated um I mean we’ve invested billions and billions of dollars into chemotherapies and all these Technologies and and immunotherapiesHarnessing the Immune System’s Power: A Deep Dive into Immunotherapy Imagine your immune system as a well-trained army, constantly patrolling your body for invaders like viruses, bacteria, and even rogue cells that could develop into cancer. Immunotherapy is like giving… Read More they’re all based on the on the somatic mutation Theory and if that theory is incorrect the outcome uh may not be good now the the idea is that yeah we have some people that that survive massive doses of chemo and radiation and we have some people that survive these immunotherapies but we also have many many many people dying from radiation and chemo and we have many many people dying from immunotherapies in the form of what we call hyper Progressive• Moving forward or developing in stages. • Favoring change, improvement, or new ideas. Examples: • A progressive disease is one that gets worse over time. • Progressive education: teaching methods focused on experience and student-led learning. • A progressive politician is someone… Read More disease where the treatment actually kills the patient before the cancer does uh and you know they die from the complications of Camp what does that mean well they they probably kill the poor patient uh with the therapies you should never ever have to treat another member of our species with anything that has a remote possibility of killing them in the attempt to make their health better right it doesn’t make any sense rarely do you die from a from a low carbohydrateCarbohydrates, often called carbs for short, are organic molecules that your body uses for energy. They’re one type of fuel the body can use for energy. Carbohydrates are made up of carbon, hydrogen, and oxygen atoms, hence the name “carbohydrate”… Read More high fatFat, a macronutrient essential for life, has been both revered and vilified throughout history. It’s a source of energy, a protector of organs, and a carrier of essential vitamins. Yet, it’s also associated with obesity, heart disease, and other health… Read More diet taken in small amounts you don’t die from that I don’t know anybody who’s died from that you know but you you’re you struck a real a nerve there and you have to ask folks that are irradiating people and you treating them with very toxic drugs why are you doing that you know what is the oh no this is what we all do well well all I mean you just have to do it because everybody else is doing it I mean you have no functional brain cells you can’t look and see that this may not be working working well you know so I look at this and I’m saying it’s going to change yeah absolutely will it change because we’re not going to continue to do this crazy stuff for another hundred years we just can’t allow all these good folks to be dying and poison irradiated suffering miserably you know surgically mutilated I mean you you can’t believe the horror stories that are going on in these cancer clinics uh treating people it’s almost medieval in in what we’re doing to these poor folks only because we have a business model in place that can’t change so um anyway it’s it’s got a it’s got a lot of things going with it it’s a very systemic problem I think because I mean to what extent are the doctors not allowed to be open with their patients about alternative treatments because of you know pressure on them yeah well I think that’s an important point I think there has there has to be some flexibility uh right now the AMA American Medical Association in fact it’s not all you am it’s everywhere I I don’t find everywhere I go on the planet they’re doing the same kinds of crazy stuff um you know it seems to be some sort of uh I don’t know uh the an effect on the on the whole institution why you have to do this stuff no matter you go to South South Africa I mean they’re doing the same thing there that they are doing in Dana-Farber Cancer Center here in Boston or MD Anderson all this they’re all doing the same kinds of crazy stuff everybody’s trying to Gene sequence stuff everybody’s looking for signaling Cascades and you know and I said why you pull the plug on their fuels they die well you have to worry about all this other stuff what are you worried about all this kind of crazy stuff for when you when if the cell dies and the patient is healthy and looking good you know uh why are you worried about all these minutia stuff and um yeah so there’s a lot of issues here you know it’s that we have to come to realize the the most important thing is to recognize that cancer is a mitochondrial metabolic disease and we’re we’re correcting Otto warburg’s original observations showing where he was correct and where he was not correct and we’re uh polishing up that whole concept we’re going to come out with a major paper showing how Otto Warburg was in fact right about the origin of cancer unfortunately uh Warburg never knew or wasn’t able to take his knowledge and develop it into an effective therapeutic strategy so we’re doing that so we’re cleaning up warburg’s uh ideas showing where he was right and how and where he wasn’t and then we’re developing a therapy based on that and that will eventually become the standard of care for cancer what was his theory on the origin of cancer which you say remains yeah what uh Warburg a very interesting uh character uh Sam Apple just wrote the book uh ravenous that describes warburg’s I mean he was an interesting character it was from his work from the 1920s on after he got out of the first world war oh yeah you should read the story he was a aristocratic uh German from the Prussian area of Germany and uh his whole history of friends and family were all of these very successful businessmen and scientists but um he knew early on that uh cancer had a very unique metabolic phenotype they fermented they you know the nice thing about the the interesting thing Warburg clearly showed I mean if you took a a rat with a tumor on its body and gave the rat cyanide cyanide kills people real quick you know it takes iodide you’re dead within within one minute but uh the the rat died instantly but the cancer cells were fine so uh they don’t need oxygen that’s what I’m saying these cancer cells can live in cyanide yeah yeah so so if a person if a person were to have a tumor in their body and they would say well I don’t want to live on the planet anymore I want to take my own life they would take the cyanide they would be dead but their tumor would be fine I know it’s nuts but it sounds nuts but Warburg did some of those experiments years ago and that told us right away that cancer cells don’t need oxygen for survival so what do they need and they ferment and he said that and then the gene the the gene crazies got involved with this and they said oh no it’s all a genetic thing no it’s not the gene mutations are an effect of the damage the deoxidative phosphorylation we’re trying to straighten this out it’s unbelievable but when you have uh ideological Dogma when you it’s you cannot change the brain of a dogmatic of a ideal lock um there’s no way you’re going to get some guy who is a devout member of one religion to immediately abandon it and jump into the other that’s called ideology it’s a it’s a it’s like a paralysis of of thinking and we see it’s everywhere it’s a paralysis of thinking so when you have scientists that are absolutely lockstep with the idea that cancer is a genetic disease no matter what you say no matter what evidence you present these guys just can’t accept it as if it were some sort of a religion they’re in their involvement so uh so we’re we’re going for the people let the people make the determination the more and more stage four cancer patients that survive um uh they say well how come you’re alive and everybody else is not you say well I did metabolic therapy oh I want to know about that what do you have to do and we’re writing out the treatment protocols now as we speak So eventually clinics will be set up to do this and more and more people will be surviving as the result of this it just takes time I’d like to get into the particulars about those trials but I cannot help but see the parallels between this illusion of consensus that we see in all spheres of Science and professions it’s uncomfortable to have to change your mind oh yeah it’s it’s very uncomfortable to have to change your mind and admit that you might have been wrong and also uh uh when you’re well paid to to think it’s very hard to get somebody to believe something when their salary depends on the not believe in it that was from Upton Sinclair up to Sinclair said that so so yeah I mean the the amounts of Revenue generation from treating cancer uh it could be you know one of the interesting things that I I just found out that um in the Wall Street Journal you can find out an awful lot about cancer just by reading the Wall Street Journal um that really tells you what’s going on in the cancer industry you know where the stocks are up oh yeah I in my cancer class I have my students read The Wall Street Journal you can get more information about cancer from that from that uh media publication than you can from any of the scientific textbooks you know it just shows you where all the energy in the in the field of cancer is going but you know one of the interesting things that came out was that the the attempts of the democratic Administration in the United States was to reduce drug costs uh the cost of medications because you know in the United States we pay more for medication than almost everybody else pays for this so one of the big plans from the Biden Administration was let’s reduce let’s reduce the cost of medications one of the consequences with that is now there’s the shortage of cancer drugs drugs for the cancer uh field because they said well if you’re going to reduce the Dr the price we’re going to make less of these drugs so so what you have now is a shortage of cancer drugs and yet when you do metabolic therapy one of the things interesting about metabolic therapy is you don’t need many drugs the amount of drug that you need now can be one-tenth what it used to be and it works even better these cancer drugs will work better when administered under metabolic approach when in a nutritional ketotic State you don’t need much drugs so actually this could work out really well for everybody we don’t have enough drugs the drugs the lower drugs will work even better when you have metabolic therapy so just it just takes time for people to understand all this you know it’s just that’s what concerns me though because I mean you posited the theory of cancer as a metabolic disease um you know with a variation on warbig’s initial Theory more than a decade ago it was well read it was picked up it’s 10 years or more later and they haven’t been sufficient trials people are still sticking to the genetic theory what’s different now that these trials will go ahead yeah yeah well you have to realize we have two issues here one is the one I told you about the The Institute changing institutions is not easy the other the other the other um blowback that we get within the scientific field and the same the same era that Warburg made from the initial uh observation was oxygen consumption so if you study cancer most people do research in cancer cells growing in in a culture dish not as much they do a lot of work of course in in Vivo model systems uh pre-clinical model systems but they also study a lot of cancer research in the cultured dish well if you look at the oxygen consumption of cultured cancer cells you say they take in tremendous amounts of ox some of them not all of them uh they take in oxygen and one of the great uh Mis misconceptions which we have now resolved we and others the oxygen consumption doesn’t mean oxidative phosphorylationOxidative Phosphorylation: The Body’s Power Plant Energizing Life: Understanding Oxidative Phosphorylation (OXPHOS) Have you ever wondered how your body transforms the food you eat into the energy you need to move, think, and simply exist? It’s a complex process, but… Read More is normal so people were looking at oxygen consumption as if mitochondria were healthy in cancer cells therefore the mitochondrial metabolic Theory cannot warburg’s Theory cannot be correct because the cancer cell is sucking down oxygen at the same rate as some normal cells therefore Warburg must be wrong now what happened we showed that the oxygen consumption in the cancer cell is not used for energy it’s used to make reactive oxygen speciesImagine oxygen as a life-giving breeze, essential for our survival. However, this breeze can sometimes turn into a gust of wind, creating chaos and destruction. Reactive Oxygen Species (ROS) are like those turbulent gusts within our bodies. They are unstable… Read More Ros cause the mutations in the nucleus so where the cancer cell is taking an oxygen but it’s like uh it’s like missing it’s like incorrect it’s not using it for energy so that show shows that Warburg himself made this kind of same mistake and so they got into this big brouhaha in the scientific field oh the cancer cell has normal mitochondria oh no the cancer cell has abnormalWhat does “abnormally” mean?”Abnormally” means something is different from what’s usual, regular, or expected. It’s like something is out of the ordinary. Imagine you have a line of evenly spaced trees. If one tree is much taller or shorter than… Read More mitochondria you know all this other stuff so we’re we’re clearing all that mess away we’re clearing straighten it out cancer cells cannot use oxygen and any way to generate uh it’s not sufficient let’s go this way no cancer cells cannot use oxidative phosphorylation alone to survive they have to have fermentation they must have fermentation driven by glucose and glutamine so the strategy for managing cancer becomes very very clear how to do this except that you have this so people will say well you know I don’t know if you’re right we have to reproduce and reproduce dozens of there’s always some non-scientific argument to say why why you can’t nobody wants to change they want to continue to do what they do so uh but yet we have all these die we have in the con in this country we have one over almost 1700 people a day dying from cancer every day for some kind of argument that we have solved along with with Warburg so I just find that we’re sacrificing human beings uh for reasons that don’t have to happen and but the institutions to change it’s just so hard and it’s too radical for them to change at this point in time so we must have these poor cancer patients suffer and die as the result of this of this conundrum how are you funding your trials my support from my research comes largely from private foundations and philanthropy there are people on this planet that understand what I am doing and they are they don’t really care whether they make a buck on it or not they just want to be part of the chain the revolution that’s coming it’s the revolution in medicine based on this that’s coming and some people say you know I might want to I want I might want to be thought of as being a part of this change and there’s a movie coming out called the cancer Revolution that’s based largely in the stuff that we did and we’re now we’re beginning to collect all of these so-called flukes these guys that had all these stage four cancers that are all doing fine as the result of doing metabolic therapy so you know when they say where’s your clinic I can’t believe anything until you do a clinical trialUnveiling the World of Clinical Trials: Your Guide to Understanding Research Participation Imagine a group of explorers venturing into uncharted territory, seeking new discoveries that could benefit humanity. In the world of medicine, clinical trials are those expeditions, carefully designed… Read More you know that’s as well you know even if you do some of this stuff they still drag their feet we did it for epilepsy and they still want to use drugs when we show clearly showed ketogenic diet was to do for her epilepsy but you know who’s going to fund the clinical trial to show that we can manage cancer effectively with yeah right I mean who’s going to step forward to do this right so what we have to do is we have to continue to show large numbers of people who continue to survive and they become Advocates and then people are going to say what did you do how did you do that you know I did metabolic therapy and and we’re in the process now of writing a very comprehensive treatment protocol so that Physicians will know exactly what to do and how to do it for the majority of cancer patients the the Pet ScanUnmasking the Mysteries of PET Scans: A Comprehensive Guide Imagine peering into the inner workings of a bustling city, observing the flow of traffic, the energy consumption of buildings, and the activity of its inhabitants. A PET scan (Positron Emission… Read More management liquid biopsies we can do an awful lot of things we can we can dovetail a lot of the newer Technologies into metabolic therapy so we just have to rearrange some of the some of the chairs but we can still bring a lot of the same uh evaluation techniques that that are currently being used into the new into the new plan except that now we don’t have to really use such toxic and expensive poisons and things to to manage the disease and I think the outcome is going to be really really good for man managing managing cancers you know and as far as the the prevention goes people say oh man listen most people are there they don’t do prevention you know um so it’s really what you’re going to do once I have cancer once the person has cancer what can you do for me um and that’s where this that’s where the big programs are going to come in management effective management so what would you just briefly recommend as for events to measures well a prevention you know you as I said the origin of cancer comes from chronicChronic simply means “happening over a long period of time” or “of long duration.” Imagine a situation that keeps going on and on, unlike something short-lived. • Other Names: You might not encounter many other terms for chronic in everyday… Read More damage to the mitochondria and the ability of that organelle to produce energy through oxygen so there are any number of ways by which cancer can occur in a person uh over uh many many years through chronic disruption of of energy metabolism in some cell and some tissue in some organ and as I said if your mitochondria remain healthy you won’t get cancer or cancer would be extremely rare as it was in our Aboriginal uh ancestors and the folks that are still uh following traditional ways very rare and as I said Albert Schweitzer who actually did a lot of his work in Africa um he evaluated some 40 000 people I think Tim knox’s book uh it talks about how many people Albert Schweitzer looked they didn’t find cancer he said why these people have no cancer because they were following their traditional ways they had a lot of exercise uh they had a lot of low carbohydrate Foods in their diet and um your body is so resistant to cancer in order to to get cancer you really need to abuse your body chronically for long periods of time because we’re designed not to get cancer just like the chimpanzee doesn’t get cancer the gorilla orangutans these kinds of things and they’re under constant surveillance all the time in these in these zoos um and then when I I went to the the zoo out there in San Diego where they have these bonobos and and and other of these other kinds of things and and I said how come you guys do you ever feed them jelly donuts and pizza and stuff like oh no no that’s called that would be animal cruelty I said well they have the same genetics as we are hi sister well we have diabetes heart disease Wellness the cancer um we’re pounding down you know Big Macs and all kinds of stuff and then we wonder why we’re getting cancer the chimpanzee well you don’t want to eat the you know wait I you don’t want to go on a chimp diet either you gotta eat or monkey meat and eat insects and stuff like that apart from carcinogensA carcinogen is something that can cause cancer. It can be a substance, like a chemical or radiation, or even a behavior like smoking. But why is this word used, and how does it connect to cancer? Etymology of Carcinogen:… Read More and information and these kinds of things that you can scientifically see the process by via which they make you sick and get cancer what about human beings that live healthy lives they don’t smoke they’re not drinkers they exercise what is the possible scientific explanation or biological explanation for them to just one day get cancer well you know we have to look at our environment and the environment that we’re in you know most of most western societies now it’s not it’s not just one thing that could produce uh cancer I mean you have a diet a lifestyle issue you’re also exposed uh to all kinds of things in the environment you know in our in natural environments I mean we’re driving on highways that have all kinds of toxic material coming out of cars where where we’re just we just have a a new environment different from our ancestral environments like the Paleolithic time of our existence and some of the as I said the Aboriginal tribes where cancer is very very low so what is it in our Western diet and lifestyle issues that could provoke cancer uh we we have oncogenic virusesA virus is a tiny, infectious particle that can invade living cells and hijack their machinery to reproduce. Imagine them as microscopic hitchhikers that need a host (like you!) to survive and multiply. Viruses aren’t quite alive on their own,… Read More we have intermittent hypoxiaHypoxia, a condition characterized by insufficient oxygen levels in tissues, is a critical threat to cellular health and function. Imagine your body as a bustling city, with oxygen as the essential fuel powering its activities. Hypoxia is like a power… Read More sleep apnea we have a lot of different things combined and people say well I don’t know I eat a very healthy diet lifestyle well what is that diet in a lifestyle you know what are your GK what is your glucose levels and ketones when we evolved as a species we were always in some level of ketosis because we didn’t have any carbohydrate High highly processed carbs in our environment so you know uh we we have things today that are very very different and and this explosion of cancer has only happened over the last you know 7 500 years I mean it’s not like it was always with us uh we we didn’t just all of a sudden hey you know everybody’s got cancer now it’s it’s happening as the result of our technological environment the lifestyle that we’re Western Society Lifestyles come into a into an environment and people start getting cancer type 2 diabetes cardiovascular disease they’re all related to the same problem you know chronic inflammationChronic inflammation is like a fire smoldering in your body for a long time. It’s different from the acute inflammation you experience with a cut or a bruise, which is a short-term response to heal an injury. Chronic inflammation, however,… Read More My ultimate question is if there’s a possibility that stress and negative energy and something that can biologically sort of work its way into your system and manifest physically is that scientifically possible absolutely the the uh chronic stress depression a lot of these things are also provocative agents leading to dysfunctional respiration and mental illness I mean there’s a lot of things that could be going on here any one of which are usually combinations of them so it’s very hard to pinpoint exactly uh why such and such a a person may may have this disease or chronic disease or that chronic disease but you know uh in cancer we we certainly know there are a number of provocative agents that can damage oxidative phosphorylation that is mitochondrial respiration and you combine that with several of the other things and all together you put yourself now at risk for at risk and then people say Well it must be genetic because we have these inherited genes uh in that run in families that put you at like bracha one mutation some of these but there we’ve looked into every one of those and and every one of those uh damages oxidative phosphorylation in one way or or another so the origin of the cancer is is damaged mitochondrial function whether it’s caused by a chemical in the environment or an inherited risk factor that you have in your genome but the the re the reason why it’s not a a a primary or is primary risk factor is every time you have that insult you always get the outcome like we have Huntington’s disease people who have the mutation in the gene Huntington 100 of the people that have that mutation will develop Huntington’s disease but we have never found the mutation in cancer inherited that’s a hundred percent penetrant like the highest level is the Lee from any mutation which is a gene mutation in the gene called p53 and uh that’s about an 85 percent penetrate meaning 15 of the people that have that mutation don’t get the cancer in order to get you have between the secondary primary cause versus secondary cause primary cause is there 100 of the time a secondary cause may or may not be a hundred so no we have not found any cancer Gene that’s 100 penetrant meaning that the inherited mutations are secondary risk factors some of them can be very high some of them can be low like for bracket one you know fifty percent of the people with the mutation develop a a a a mutation develop a cancer of the breast or or maybe another organ but that means about 50 of the women that have that don’t so so in order for something to be a primary cause 100 everybody who has that has to develop so we have inherited mutations as risk factors combined with environmental insults that can increase the probability of of of of manifesting the condition so you have to weigh all these things together and every woman that has a breast tumor whether it’s from chemical carcinogen smoking or bracha one they’re all fermenters so bottom line is that whatever tumor arises from the provocative agent the cells in that tumor will be fermented glucose and glutamine so you know how to now you know how to manage them regardless of what the origin happens to be but is Baraka not a sort of exception of a gene that you must sort of look out for I mean that’s one of the reasons I mean you can test for it but say your parents had Non-Hodgkin’s lymphoma yeah what does that mean for you well it it you know it depends on the environment that the person is in to to generate Non-Hodgkin’s lymphoma there might be some Gene risk factors that could uh put you at risk in the right environment but there’s no Gene that will be 100 responsible for whether or not you get Non-Hodgkin’s lymphoma or any any cancer for that matter just to close off with can you tell me about the first step of your trial when does it start yeah we have to write the protocol first number one number two you have to have a trained staff of Physicians that understand how to do this that’s that’s another thing and number three you have to have a place to do this so um normally hospitals would do this uh a trial like this but unfortunately we have not yet found a hospital willing to do a trial the way we would want to specify it that’s because of the institutional review review boards the IRB makes a decision as to whether or not you can do something in that hospital we know that in the brain cancer field they they will do metabolic therapy only after radiation and chemo fails which fails all the time anyway so they will not allow metabolic therapy to be done as a standalone it has to be done with radiation so therefore we have to find a new venue uh to to allow us to do what we think uh should be done and then we have to train people to do it we have to we have all of this in our treatment protocol once we have the treatment protocol published then it becomes a how-to manual on how to start this and then we need to train the Physicians um to know the concepts behind this why what are they doing why are they doing it what should they be looking for how how can we modify the plan uh when we see things arise it’s not like one shoe fits all um you know patients have to come in we do blood work we figure out how healthy they are a lot of folks that have cancer have diabetes diabetes they have high blood pressure they have hypertension they have all kinds of other issues you know you got to start managing some of those things before you can start using the kinds of drugs that will be selectively killing tumor cells so there’s a lot of things that go go into this um but you know we have to write the protocol first we have to let people know if you see this and you see that what do we do how do we do it at what point do the does the patient now receive the kinds of drugs dosage timing and scheduling of these drugs that work together with the diet so I’m just giving you a kind of a snapshot of what’s going to take place eventually yeah at just this may have been quite a few years ago but your question is saying that you would use chemotherapyChemotherapy (often shortened to “chemo”) is a type of cancer treatment that uses powerful medicine to destroy cancer cells. It works by stopping or slowing down the growth of fast-dividing cells, and cancer cells happen to grow and divide much… Read More alongside metabolic theories is this no longer the case no I think we can still do that I I think that as again as like I said we can use far far lower dosages see they have they have a standards that they uh that are instituted almost everywhere uh in major major cities in around the world you have to have if you follow a protocol for cisplatin or lock these other drugs that they have lubastine and whatever else you know there’s a dosage range from the lowest to the highest um but you know I think those low doses can be lowered uh much more than what they recommend uh we don’t need especially if the patient is in therapy therapeutic ketosis or water only fasting you can get that you can these drugs will kill cancer cells for sure but you want them to kill cancer cells more selectively than her arm your normal cells and that’s why when you transition the body to nutritional ketosis you give the drugs a greater opportunity to kill the tumor cells with less toxicity so that’s another phase of of of of of where we’re going and that’s why we don’t need much of these chemotherapy drugs you just need a little bit of them uh knowing when to use them and how to use them at what point um even immunotherapies like if we have a raging tumor in a brain or a colon or a lung and we bring it down to a small small tiny little spot and we know that all the cells in that spot will have something in common because they were able to survive metabolic therapy you might now be able to come in with a drug or an immunotherapy and knock them off real quick you just don’t do it at the beginning you just have to know how to use the tools that you have and right now we’re not knowing that we don’t know how to do that and we’re trying to tell people yeah we can help you learn how to do this in the best way to achieve the greatest outcome foreign